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Search Results for " hep g2 "

14

抑制剂 & 化合物

15

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T1579	Mestranol Devocin,Norquen,美雌醇,Menophase	Estrogen Receptor/ERR; Estrogen/progestogen Receptor	Endocrinology/Hormones
	Mestranol (Devocin) 是一种雌激素受体激动剂，是一种非活性的前药，在转化为炔雌醇时具有生物活性。动物实验中，它可以与黄体酮联合使用，它可用于更年期激素或月经紊乱的研究。
T71610	Docosylferulate
	Docosylferulate is a biochemical that has been studied for its inhibition on Hep G2 cells and anti-tumor activities.
T73421	CPT-Se3	Topoisomerase	DNA Damage/DNA Repair
	CPT-Se3为含硒的喜树碱前体活性分子，其杀癌和抗肿瘤效力显著。它通过降低GSH/GSSG比率及总硫醇水平，增加Hep G2细胞中ROS含量，触发癌细胞凋亡。CPT-Se3对HeLa、Hep G2、A549及SMMC-7721细胞线具备显着细胞毒性，IC50值介于2.19-4.7 μM。
T30111	AR 12465 AR-12465
	AR 12465 is a trapidil derivative which may affect LDL receptor mediated uptake and degradation of 125 I-LDL by human skin fibroblasts (HSF) and human hepatic cells (HEP G2).
T63304	Topoisomerase II inhibitor 9
	Topoisomerase II inhibitor 9 是 Topo II 抑制剂 (IC50: 0.97 μM)，也是 DNA 嵌入剂 (IC50: 43.51 μM)，能够在 G2/M 期阻滞 Hep G‐2 细胞周期，诱导细胞凋亡 (apoptosis)。
T62905	GLS-1-IN-1
	GLS-1-IN-1 (compound 1d) 是一种 GLS-1 抑制剂，能够抑制 Hep G2、MCF 7 和 MCF 10A 细胞。
T78068	O-allylvanillin	Others	Others
	O-allylvanillin为o-烯丙基查尔酮衍生物，呈现抗癌活性。该化合物对THP-1、HL60、Hep-G2、MCF-7细胞系生长抑制作用显著，其IC50值依次为74.76 μM、63.52 μM、90.99 μM、90.11 μM。
T76527	Hepatitis B Virus Receptor Binding Fragment
	Hepatitis B Virus Receptor Binding Fragment（hepatitis B peptide 4980）为一合成肽类似物，特异性结合Hep G2细胞。基于病毒中和粘附阻断理念，此Fragment可望激发保护性抗体生成，展现作为免疫原的巨大潜力。
T79915	Antioxidant agent-15	COX	Immunology/Inflammation; Neuroscience
	Antioxidant agent-15 (Compound 4) 显示出显著的抗氧化抑制活性，其 IC50 为 15.44 nM。在细胞水平上，Antioxidant agent-15 对Hela、Hep G2 和 Caco-2肿瘤细胞生长的抑制作用各自具有不同的 IC50 值，分别为 395.26 nM、4000.4 nM 和 24.6 nM。
T73422	CPT-Se4	Topoisomerase	DNA Damage/DNA Repair
	CPT-Se4为含硒前体活性分子的喜树碱(CPT)衍生物，对癌细胞具有较高杀伤力和抑制肿瘤生长效果。在降低GSH/GSSG比率和总硫醇的同时，CPT-Se4能够增加Hep G2细胞中的ROS水平，触发癌细胞凋亡。此化合物对HeLa、Hep G2、A549和SMMC-7721细胞系显示出显著的细胞毒性，IC50值范围为2.54-6.4 μM。
T62405	KDM1/CDK1-IN-1
	KDM1/CDK1-IN-1 (compound 4) 是一种有效的 KDM1 (IC50: 0.096 μM) 和 CDK1 (IC50: 0.078 μM) 抑制剂。KDM1/CDK1-IN-1 能够将 HOP-92 细胞的细胞周期阻滞在 G2/M 期，并诱导其凋亡 (apoptosis)。KDM1/CDK1-IN-1 对 CCRF-CEM 细胞 (IC50: 16.34 μM)、HOP-92 细胞 (IC50: 3.45 μM) 和 Hep-G2 细胞 (IC50: 7.79 μM) 具有较强的细胞毒性。
T82493	EGFR/HER2/DHFR-IN-2	EGFR	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	EGFR/HER2/DHFR-IN-2 (Compound 4b) 是针对EGFR、HER2和DHFR的三重抑制剂，IC50分别为0.248、0.156、0.138 μM。该化合物对包括Hep G2, HeLa, HEp-2, HCT 116, PC-3, MCF7在内的多种癌细胞系展现出显著的抗癌活性(IC50分别为9.14、7.33、14.18、24.87、20.07、6.16 μM)，并能有效减缓乳腺癌肿瘤的生长。
T78855	Anticancer agent 157	NO Synthase	Immunology/Inflammation
	Anticanceragent 157（compound 15）是一种NO抑制剂，具有抗炎和抗癌特性，IC50值为0.62 μg/mL。它能够与iNOS和caspase 8结合，进而导致核断裂和染色质浓缩，从而诱导细胞凋亡。此外，Anticanceragent 157在不同癌细胞系中展现出显著的抑制活性，对HT29结肠癌细胞的IC50为2.45 μg/mL，对Hep-G2肝癌细胞的IC50为3.25 μg/mL，以及对B16-F10鼠黑色素瘤细胞的IC50为3.84 μg/mL。
T78588	Cochliodone A
	Cochliodone A 是一种从深海衍生真菌Chaetomium sp.培养物中分离的活性化合物，展示出了抗细菌和抗癌的特性。该化合物对多种细菌显示出有效的抑制作用，其最小抑菌浓度（MICs）分别为：V. vulnificus 15.3 μg/mL，V. rotiferianus 32.7 μg/mL，S. aureus ATCC 43300 15.9 μg/mL 和 S. aureus CGMCC 1.12409 16.3 μg/mL。Cochliodone A 同时对不同的癌细胞系也有抑制效果，其半数抑制浓度（IC50s）分别为：A549 28.1 μM，HeLa 20.7 μM，和 Hep G2 23.2 μM。

化合物

Cat.No: T1579

Synonym: Devocin,Norquen,美雌醇,Menophase

Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor

Docosylferulate

Cat.No: T71610

Cat.No: T73421

Target: Topoisomerase

Cat.No: T30111

Synonym: AR-12465

Topoisomerase II inhibitor 9

Cat.No: T63304

Cat.No: T62905

O-allylvanillin

Cat.No: T78068

Target: Others

Hepatitis B Virus Receptor Binding Fragment

Cat.No: T76527

Antioxidant agent-15

Cat.No: T79915

Target: COX

Cat.No: T73422

Target: Topoisomerase

Cat.No: T62405

EGFR/HER2/DHFR-IN-2

Cat.No: T82493

Target: EGFR

Anticancer agent 157

Cat.No: T78855

Target: NO Synthase

Cat.No: T78588

Cat. No.	Product Name	Target	Signaling Pathways
T5654	Musk ketone	Others	Others
	Musk ketone 可诱导癌细胞生长抑制和凋亡。它增加谷胱甘肽 S-转移酶的活性，因此可能被证明是有用的癌症化学保护剂。
TN2225	Soyasapogenol B 大豆甾醇 B,大豆甾醇B	Apoptosis; Autophagy	Apoptosis; Autophagy
	Soyasapogenol B 是大豆的一种成分，具有降胆固醇、抗补体和保肝作用。它抑制培养的 Hep-G2 的增殖，可触发内质网应激反应，其介导结肠直肠癌中的细胞凋亡和自噬。
TN4562	Oleoside 11-methyl ester 木樨榄苷-11-甲酯,Methyloleoside	Others	Others
	Oleoside 11-methyl ester (Methyloleoside) 是一种对 Hep-G2 细胞具有强细胞毒作用的裂环烯醚萜苷。
TN5941	2,3-O-Isopropylidenyl euscaphic acid 蔷薇酸丙酮化物,Euscaphic acid acetonide
	2,3-O-Isopropylidenyl euscaphic acid shows good hepatoprotective effect,the EC50 value of 88.36±3.25 uM in Hep G2 cells.
T13897	Soyasaponin III	Others	Others
	Soyasaponin III is one of the main potentially bioactive saponins found in soy (Glycine max) and related products,and can induce apoptosis in Hep-G2 cells.
TN3728	Cudraxanthone L	Others	Others
	Cudraxanthone L shows the significant hepatoprotective effect on nitrofurantoin-induced cytotoxicity in human liver-derived Hep G2 cells.
TN4843	Pterisolic acid A	Others	Others
	Pterisolic acid A shows moderate activity against HCT-116,Hep G2 and BGC-823 cell lines.
TN5961	Gardenolic acid B
	Gardenolic acid B shows promising hepatoprotective effects on nitrofurantoin-induced cytotoxicity in human liver-derived Hep G2 cells. Gardenolic acid B shows significant effects on terminating early pregnancy in rats.
TN4711	Onitin	Others	Others
	Onitin shows super-oxide and DPPH free radical scavenging effects.It also exhibits hepatoprotective activity on tacrine-induced cytotoxicity in human liver-derived Hep G2 cells.
T81365	Protoapigenone
	Protoapigenone 是一种可从蕨类植物中分离得到的抗肿瘤剂。该化合物对 Hep G2、Hep 3B、MCF-7、A549 及 MDAMB-231 肿瘤细胞系展示了显著的抑制活性，其 IC50s 分别为 1.60、0.23、0.78、3.88 和 0.27 μg/mL。
TN1464	Camellianin A	RAAS	Endocrinology/Hormones
	Camellianin A has anticancer activity, it can inhibit the proliferation of the human hepatocellular liver carcinoma Hep G2 and human breast adenocarcinoma MCF-7 cell lines in a dose-dependent manner and induce the significant increase of the G0/G1 cell po
TN5154	Torilolone	Others	Others
	Torilin and torilolone show hepatoprotective effects on tacrine-induced cytotoxicity in human liver-derived Hep G2 cells,the EC50 values are 20.6 +/- 1.86 and 3.6 +/- 0.1 microM, respectively; and silybin as a positive control shows an EC50 value of 69.0
TN1368	Alisol C	Others	Others
	Alisol C can improve glucose uptake in Hep G2 cells, it may be one of the therapeutic material basis in hypoglycemic activities in A. orientalis. Alisol C,16,23-oxido-alisol B and alisol O in Zexie may cause nephrotoxicity.
TN5901	Cudratricusxanthone A
	Cudratricusxanthone A has potent anti-proliferative, antioxidative, and monoamine oxidase inhibitory effects, it also possesses anti-cancer activities and provide a basis for developing effective therapeutic agents to inhibit growth and metastasis of brea
TN2190	Scoulerine	Apoptosis; Beta-Secretase; BACE; Parasite	Apoptosis; Microbiology/Virology; Neuroscience
	Scoulerine 是抗有丝分裂化合物。它抑制细胞增殖，阻止细胞周期，并诱导癌细胞凋亡。它也是BACE1(淀粉样前体蛋白裂解酶 1) 的抑制剂。

天然产物

Cat.No: T5654

Target: Others

Soyasapogenol B

Cat.No: TN2225

Synonym: 大豆甾醇 B,大豆甾醇B

Target: Apoptosis, Autophagy

Oleoside 11-methyl ester

Cat.No: TN4562

Synonym: 木樨榄苷-11-甲酯,Methyloleoside

Target: Others

2,3-O-Isopropylidenyl euscaphic acid

Cat.No: TN5941

Synonym: 蔷薇酸丙酮化物,Euscaphic acid acetonide

Soyasaponin III

Cat.No: T13897

Target: Others

Cudraxanthone L

Cat.No: TN3728

Target: Others

Pterisolic acid A

Cat.No: TN4843

Target: Others

Gardenolic acid B

Cat.No: TN5961

Cat.No: TN4711

Target: Others

Cat.No: T81365

Cat.No: TN1464

Target: RAAS

Cat.No: TN5154

Target: Others

Cat.No: TN1368

Target: Others

Cudratricusxanthone A

Cat.No: TN5901

Cat.No: TN2190

Target: Apoptosis, Beta-Secretase, BACE, Parasite

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